25, 26 Owing to spatial compartmentalization, reaction kinetics and physiological functions of low ROS concentrations, the scavenging of ROS by cellular enzyme systems (for example, superoxide dismutase, catalase) is impaired
This ultimately leads to increased mitochondrial DNA replication, elevated cellular mitochndrial numbers, and significantly enhanced mitochondrial biogenesis capacity [6466]
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F., Wilson, B., Jackson-Lewis, V., Przedborski, S., Joset, D., Loike, J., Hong, J