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The histone tails are susceptible to the inclusion of a set of chemical groups, including methyl groups from SAM donation (Triantaphyllopoulos et al., 2016) ( Figure 1 )

Acknowledgements The authors thank Professor Genji Qin (Peking University, China) for providing the vps29 mutant and Professor Ruixi Li (South University of Science and Technology, China) and Professor Caiji Gao (South China Normal University, China) for providing the snx1/snx2a/snx2b mutant

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Studies suggest that isoniazid-induced DILI is under-reported, with the US DILI network finding it as the second most common risk

The second channel of this pyrometer was tuned to 488 nm, the wavelength of a lower power (1 W) Ar + laser that was focussed on and reflected by the melting/freezing sample surface