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Diffuse hyperpigmentation and gingival darkening were reported and reportedly recurred after re-exposure

A gut feeling of statin: How gut microbiota modulate the therapeutic and side effects of statins

Gastrointestinal Irritation In some cases, digestive changes caused by medication may lead to irritation in the gastrointestinal tract

These findings suggest that GIP but not GLP-1RA may improve glucose disposal by ameliorating peripheral insulin sensibility and glucose utilization, while GIP added on to GLP-1RA may reduce food intake with a combined effect resulting in improvement of glucose control and weight loss

In controlled clinical studies as both monotherapy and combination therapy with metformin, pioglitazone, or rosiglitazone and metformin, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo

At 68 weeks, the treatment-regimen estimand results were -20.0% (9 mg dose, approximately 50.5 pounds) and -23.7% (12 mg dose, approximately 60 pounds)