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Biddinger KJ, Emdin CA, Haas ME, Wang M, Hindy G, Ellinor PT, Kathiresan S, Khera AV, Aragam KG

Engrafted human induced pluripotent stem cell-derived cardiomyocytes undergo clonal expansion in vivo

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These changes help cells survive and grow, but the root cause of cancer remains the accumulation of genetic mutations that disrupt normal growth control. These mutations can affect multiple metabolic pathways, which explains why enzymes like NAMPT are altered

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