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(2017) further supported rutins antidepressant potential by observing a dose-dependent decrease in immobility time during the tail suspension test (TST) in mice treated with rutin (Yushau et al., 2017) (Figure 3)

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Four of the studies had constant sulfonylurea dosage throughout the study (78, 79, 81, 82), whereas one study added the DPP-4 inhibitor to submaximal dose of sulfonylurea and compared this combination with up-titration of the sulfonylurea (80)