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Pharmacol Res 182:106348 Vuppalanchi R, Ghabril M (2022) clinical assessment of suspected drug-induced liver injury and its management

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Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18