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Reducing hyperpigmentation, scars, and age spots

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PMID 11779849

Older trials and reviews report mild transient headache, nausea, and occasional dizziness

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These comparative studies establish the pharmacological basis for the different biological profiles of MT-1 versus MT-II , with MT-1s MC1R preference explaining its predominantly pigmentary and skin photoprotection biology in contrast to MT-IIs broader melanocortin receptor activation producing pro-sexual, pro-erectile, and central appetite effects alongside pigmentation