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Concentrations above 2% w/v (20mg/mL) risk copper salt precipitation and peptide instability, reducing bioavailability and potentially causing skin irritation from free copper ions

Metalloproteins contain coordinated transition metals which can be substituted by chemically similar other transition metals (Table 2)

J Clin Endocrinol Metab (1997) 82(12):4196200.10.1210/jcem.82.12.4450 107 HolmesAGMesaJLNeillBAChungJCareyALSteinbergGRet alProlonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats

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C) is a Naturopathic Endocrinologist and the author of The NY Times bestselling Hormone Healing Cookbook, The Metabolism Reset Diet, and The Thyroid Reset Diet