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Clinical trials involving investigational medicinal products (CTIMPs) in the UK are governed by the Medicines for Human Use (Clinical Trials) Regulations 2004 (as amended), with safety reporting requirements set out in MHRA and Health Research Authority (HRA) guidance

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GLP-1RA Cardiovascular Disease Outcomes Starting in 2008, the FDA began requiring all medications indicated for treatment of type 2 diabetes to evaluate cardiovascular risk reduction [45]

PT-141: A melanocortin agonist for the treatment of sexual dysfunction

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## What Comes Next in GLP-1 Development The field is evolving rapidly