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Compared to liraglutide, semaglutide has an additional amino acid substitution in the 8th position from Ala to -aminobutyric acid (Aib) to avoid degradation by DPP-4 [64]

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This analysis showed that semaglutide (both oral and sc) reduces the continuum relative and the absolute risk of MACE, especially in medium to high-risk patients, with no difference between trials evaluating only blood glucose control or cardiovascular events, and also with studies without active comparator, only versus placebo

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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.McHugh J

For a widely prescribed drug class with no prior long-term reproductive safety data in men, that null finding is itself clinically significant