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GI discomfort: Nausea or bloating can affect nutrient absorption

This is particularly relevant when discussing antacids

A 2012 study published in BMB Reports found that curcumin at concentrations achievable with high-dose supplementation (equivalent to roughly 2,000 mg/day with piperine enhancement) reduced ADP-induced and collagen-induced platelet aggregation in human blood samples by 20% to 30% [3]

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This helps maintain physiologic hormone patterns rather than overwhelming the body with synthetic GH