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The glucose-lowering agents metformin and SGLT2is are recommended by the KDIGO 2022 guidelines as first-line therapies in patients with T2D, [18] and all three guidelines recommend a RAAS inhibitor, at the maximum tolerated dose, as a standard of care for patients with T2D and albuminuria [18, 20, 84]

These symptoms often improve over time and with dose stabilisation, though patterns vary between individuals

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