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This is not well understood mechanistically but may relate to individual sensitivity, dehydration, or unrelated factors coinciding with supplement use
Your dose of tirzepatide may need to increase over time as your body builds tolerance, but B12 supplementation does not affect this progression
Cell Microbiol
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In the SURMOUNT-1 trial, participants with obesity or overweight achieved average weight reductions of 15-22% of body weight after 72 weeks, depending on the dose
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