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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Rothschild J, Hoddy KK, Jambazian P, Varady KA

Exendin-4 was eventually developed into exenatide, a treatment for diabetes and the first GLP-1 receptor agonist approved for medical use

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More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine