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Phentermine, Low Dose Naltrexone, Orlistat,etc.) were only noted to produce an average of 3-7% total percentage of body weight lost

Semaglutide increases gastric sensitivity in some users, making certain foods temporarily harder to digest

These medications also delay gastric emptying through neural mechanisms, increasing the risk for perioperative aspiration during anaesthesia and sedation

Experiments on mouse chondrocytes also revealed the added role of liraglutide in reducing inflammation by decreasing mRNA expression of inducible nitric oxide synthase, matrix metallopeptidase 13, and ADAM metallopeptidase with thrombospondin type 1 motif 5, culminating in a reduction of IL-6, prostaglandin E2, and nitric oxide[13]

Tirzepatide was approved by the FDA and EMA for the treatment of type 2 diabetes in 2022