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doi: 10.1016/S0024-3205(00)01025-0

You may be able to take a lower dose of methotrexate or time your medication to avoid nausea or fatigue

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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility SYNJARDY or SYNJARDY XR No carcinogenicity, mutagenicity, or impairment of fertility studies have been conducted with the combination of empagliflozin and metformin HCl