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"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

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If the appetite-reducing effects you normally experience from tirzepatide start becoming noticeably weaker at the same dose, degradation is one possible explanation

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