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These initiatives remain early stage and are subject to meaningful scientific, clinical and regulatory uncertainty

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Regeneron's Phase 2 COURAGE trial is testing a direct attempt to do exactly that: combine semaglutide with trevogrumab, a monoclonal antibody that blocks myostatin, one of the body's natural brakes on muscle growth

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Cochrane Database Syst Rev 1(1): CD012722

For this reason, experts advocate using only supervised clinical settings with greater regulation as a means of protecting patients