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But it's not the end of the road

He won two consecutive Academy Awards for Best Actor, playing a gay lawyer suffering from AIDS in Philadelphia (1993), then the title character in Forrest Gump (1994)

The mechanism of action involves stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

Muscle loss also reduces insulin sensitivity

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