In female users of GLP-1 drugs, those rates were 5.44% with tirzepatide versus 3.63% with semaglutide, the researchers said
The underlying mechanisms of GLP-1 receptor agonism make these medications particularly suited to addressing both conditions simultaneously
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Methods: The expression of senescent markers (p16 INK4a and p21 WAF1/Cip1 ), various SASPs such as CCL2 and interferon induced protein with tetratricopeptide repeats 3 (IFIT3), dysregulated autophagy marker p62 and PD-L1 were immunohistochemically examined in livers taken from the patients with PBC (n=87