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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

Combination therapies are being designed to target multiple pathways (e.g., curb hunger and speed up metabolism) to improve both weight loss and tolerability

I already have thyroid problems,'" Clarkson said