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For the tumour allograft model, Gclc f/f Rosa26 creERT2 MMTV-PYMT mice and control C57BL/6 mice (The Jackson Laboratory, 000664) were used (female, at least 12 weeks old)

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SeCys is then transformed into selenohomocysteine via cystathionine--lyase, and eventually converted to SeMet through the catalysis of methionine synthase (Trippe and Pilon-Smits, 2021)

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Dot plots show cell viability and lipid-ROS in HC neutrophils (n = 7) cultured with 20% HC or SLE serum supplemented with -ME (10/50 M) for 16 hours

Similarly, the first in vivo imaging studies in humans, confirmed an increase in OS and a simultaneous decrease in GSH levels in the motor cortex of patients with ALS (with an age of 65.2 9.4 years, and a mean disease duration of 25.8 17.1 months) compared to the controls [106, 107]