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Immune disorders during the acute phase of severe MDD are intricate and involve the activation of the immuneinflammatory response system (IRS), which is characterized by macrophage M1 activation and T helper (Th)1 and Th17 immune profiles, in addition to relative deficiencies in the compensatory immunoregulatory system (CIRS), which includes M2, Th-2, and T regulatory (Treg) cell profiles [2, 3]

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