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Proc Natl Acad Sci USA 105:63686373 Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

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The fundamental problem lies in competing hormonal signals

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Strong, unregulated growth signaling is useful in a petri dish and genuinely risky in a person which is the whole reason this belongs only in a medically supervised setting