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10.2174/156802610792232060 21 BraszkoJ

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Many direct or indirect markers of oxidative stress, including malondialdehyde, thiobarbituric acid, and glutathione disulfide, have been found in urine, plasma, sputum, and BAL fluid of patients with asthma, and the level of the markers correlated with the severity of the disease [6769]

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Given the differences in the PK characteristics between two formulations [15, 18, 19], the PK/PD relationships were explored at a range of dose levels: 1 mg, 2 mg, 3 mg, and 4 mg for the SC administration and 20 mg, 30 mg, 40 mg, and 50 mg for the SL administration