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In adipose tissue, Dpp4 expression is related to adipocyte size, and both insulin and the inflammatory cytokine TNF- increase shedding of soluble DPP-4 from the membrane ( Dpp4 expression in the liver of mice prone to diet-induced obesity, independently of the degree of intra-hepatic fat accumulation ( Dpp4 expression is increased following exposure to high glucose (although not to insulin) ( Dpp4 (Figure 3)

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Groups that began at 2mg before escalating experienced fewer gastrointestinal side effects than groups that started at 4mg

High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression

Neurol Neuroimmunol Neuroinflamm 2015

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