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Cohort design, covariates, and outcomes This retrospective, propensity-score-matched cohort study included obese patients (BMI 27 kg/m) initiating Tirzepatide, Semaglutide, Phentermine/Topiramate, Naltrexone/Bupropion, or Phentermine from November 1, 2023, through April 31, 2025

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Early in semaglutide therapy, reduced hunger makes calorie restriction almost effortless

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