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They are not typically associated with dependency or severe side effects, although minor issues such as nasal irritation or insomnia may occur

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Evidence for release of copper in the brain: depolarisation-induced release of newly taken-up 67Copper

doi:10.2174/157340313805076322

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at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)