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PMID 32730231

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In addition, the leptin-receptor-expressing (LepR) neural activity in the dorsomedial hypothalamus (DMH), which sends GABAergic inhibitory inputs to ARC AgRP neurons, is also known to be rapidly increased by sensory detection, the taste of food, or food cues [48,53,54]

This dose was chosen based on a previous dose-escalation study and subsequent work demonstrating its efficacy to drive weight loss in a short period of time 8