However, the import of glutathione into the nucleus under normal physiological conditions occurs at the expense of the cytosolic pool 85 which together with AITC generates an extreme demand for glutathione
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Structural changes, such as protein unfolding and aggregation, can either disrupt existing epitopes or create new ones, influencing the proteins sensitivity or resistance to gastric and gastrointestinal enzymes [119]
At the same time, iron-dependent lipoxygenase (LOX) catalyzes polyunsaturated fatty acids (PUFAs) to induce OS, which further alters the permeability of BBB (Iadecola and Anrather 2011)
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In addition, certain medications can reduce the absorption (and therefore the benefits) associated with B12