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A 2.5 mg starting dose of tirzepatide is roughly equivalent in clinical effect to a 0.25 mg starting dose of semaglutide, not because one is weaker, but because the molecular pharmacology demands different quantities to achieve similar receptor occupancy

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Thus, since Mounjaro stimulates both GLP-1 and GIP, Mounjaro is categorized as a dual agonist

Results showed that semaglutide led to greater reductions in both HbA1c levels and body weight, positioning it as a superior option in terms of glycemic control and weight-related benefits

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