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Detoxification Reactions Because glutathione supports the liver, some people experience a "herxheimer" or detox reaction, which can feel like a mild headache or slight fatigue as the body begins to process stored toxins more actively

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Efficacy of GLP-1 RA approved for weight management in patients with or without diabetes: A narrative review

Additional complications involve hormone replacement in Hashimotos thyroiditis, which usually involves the administration of levothyroxine

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This interesting finding, occurring without weight loss, is consistent with preclinical and clinical studies showing weight-independent effects of GLP-1R agonism on liver steatosis 51,52,53