Bao et al (60) found downregulation of the ferroptosis regulator GPX4 in both Fpnfl/fl/NEXcre (NEX-Cre mice were mated with Fpn-floxed (Fpnfl/fl) mice to generate conditional Fpnfl/fl/NEXcre mice.) and APPswe/PS1dE9 (Carrying genetically modified mice with AD-related mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9) mouse models compared with controls
Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
Comparative Performance Analysis: Liposomal vs
In our previous study, pharmacokinetic and pharmacodynamic analyses ( n = 145) demonstrated that L-serine exhibited greater efficacy at higher doses, with regimens equivalent to 400 mg/kg/day leading to notable increases in K-VABS-II-ABC scores (1.73.7 points vs
doi: 10.1038/srep10048 132
As lesions progress, vascular smooth muscle cells (VSMCs), crucial for maintaining structural stability of the arterial wall, also become susceptible to ferroptosis (Zhang et al., 2022)
