The incidence rate of events was 6.62% over 664.84 patient-years for the deep response group, and 14.13% over 307.75 patient-years for the adequate response group
Nevertheless, even the most effective marketed incretin, the GLP-1/GIP dual agonist tirzepatide, produces a maximum HbA1c reduction of ~2.6%, with fewer than half of participants in the SURPASS trials reaching normoglycemia (HbA1c 10%), vehicle-treated animals lost ~40% of body weight over 3 months, consistent with prior reports showing comparable reductions from ~40 g at week 10 to ~25 g by week 20 19
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However, the results are significant enough to warrant utilizing medications to help people lose weight, so that their sleep apnea improves, said Christine Ren-Fielding, MD, division chief of bariatric surgery at NYU Langone and director of the NYU Langone Weight Management Program
