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However, a recent study indicated that a combination regimen of tamoxifen and phosphodiesterase type 5 inhibitors might be effective in treating PD based on in vitro and in vivo disease models ( Phosphodiesterase Type 5 Inhibitors It is reported that phosphodiesterase type 5 inhibitors (PDE5Is) might be a potential cause of PD due to increasing rigidity via oral PDE5Is making the penile deformity more obvious and increasing the susceptibility to penile trauma during intercourse (Tsambarlis and Levine, 2019)