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Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Eagleson et al., 2016)

Oral and injectable forms may cause mild digestive discomfort or injection site reactions, and unknown systemic effects or interactions with medications cannot be ruled out

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Granata A, Maccarrone R, Anzaldi M, et al

10.1016/s0169-409x(97)00063-x 9 BocsikA.GrfI.KissL.tvsF.ZsrosO.DarukaL.et al (2019)

Infliximab treatment enhances the visual recognition memory impairment and clears the A effect on mAChR-LTD in mice [161]