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Localization of orexins-1 receptors to vagal afferent neurons in the rat and humans

Surescripts, originally known for e-prescribing, expanded its network to support ePA messages among EHRs and major PBMs (including CVS Caremark and Express Scripts) ( [39] ) ( [40] )

Their pioneering modes of action coupled with early triumphs imply that these agents may soon emerge as essential elements in overcoming challenges posed by obesity and diabetes across patient populations

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In pancreatic -cells, this results in enhanced glucose-dependent insulin exocytosis the incretin effect and also drives insulin gene expression and -cell survival and proliferation via the PI3K/Akt pathway

Funding: Supported by NIH grants P30 DK056341 (Washington University Nutrition and Obesity Research Center), P30 DK020579 (Washington University Diabetes Research Center), UL1 TR000448 (Washington University Institute of Clinical and Translational Sciences), and T32 DK007120, and the Barnes-Jewish Hospital Foundation