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While adenosine triphosphate (ATP) signaling was enhanced, capsaicin sensitivity was unaffected by the acute application of exendin-4 in cultured DRG neurons, suggesting GLP-1R role in modulating gut motility rather than pain signaling

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Reaching Your Maintenance Dose Once you reach the target maintenance dose (2.4 mg weekly for semaglutide, or 10 to 15 mg weekly for tirzepatide, depending on your providers recommendation), the treatment shifts from escalation to sustaining

Bupropion and naltrexone (Contrave): An opioid blocker combined with an antidepressant that can help reduce emotional eating

Interestingly, the obese MCAS patients tolerated the high dose quite well, while others did fine on lower doses