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Central nervous system effects may also contribute to fatigue

Current insights into pathophysiology, diagnosis and treatment

Schwartz MW, Woods SC, Porte D, Jr., Seeley RJ, Baskin DG

This pathway is critical in the UPR triggered by ER stress, which itself is exacerbated by oxidative stress conditions

For instance, the yak bone collagen hydrolysates withstand gastrointestinal digestion and significantly alter gut microbiota composition, reducing the Firmicutes to Bacteroidetes ratio by 30.8% and 36.5%, respectively, while increasing short-chain fatty acid concentrations by 50%, demonstrating their potential in functional food applications [117]

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