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The hypothalamus integrates these hormonal signals alongside inputs from the vagus nerve, which relays information about stomach distension

Finally, these observations provide a unique example of an intervention which appears to favor female healthspan and lifespan, thereby reinforcing the need for considering sex differences in devising therapeutic strategies to treat aging and its diseases

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79 According to our review, the peak incidence occurred during the 4th and 5th decades, with a balanced sex distribution