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In native physiology, the six IGFBPs perform several overlapping regulatory jobs: they extend the circulating half-life of IGF-1, they create a reservoir of hormone that can be released as needed, they modulate the amount of free peptide available to receptors, and in some contexts they exert IGF-independent effects of their own

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Retatrutide falls squarely within this expected range, and at the favorable end of it

Here, we will provide an overview of the existing literature around diabetes and metabolism in the context of cancer and cachexia