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355 Guilln, C

In: Erdman Jr J, Macdonald J, Zeisel S, eds

Nausea, vomiting, diarrhea, and constipation occur in 25-50% of patients during dose escalation, typically subsiding within 2-4 weeks

IGF-1 DES has 20-30 minute half-life, minimal IGFBP binding, highest receptor affinity and potency, localized effects at injection site, and requires frequent dosing for sustained effects

[1] [2] Semaglutide is a modified version of human GLP-1, a naturally occurring incretin hormone that plays a crucial role in glucose regulation

GLP-1 was measured with a Glucagon-Like Peptide-1 (Active) ELISA kit (Millipore), and ghrelin in an automated enzyme immunoassay system (AIA-600 II Immunoassay Analyzer, TOSOH Bioscience)