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When consumed orally, glutathione must survive the harsh acidic environment of the stomach, navigate intestinal absorption barriers, and undergo first-pass metabolism in the liver before reaching systemic circulation

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Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), formerly FSP1, mitigates ferroptosis owing to GPX4 deletion

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therefore, the level of free Nrf2 is higher in the nucleus and induces chemoresistance (Lau et al., 2010)

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