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TGF-beta-induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarring

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Could someone answer either of these questions for me.both the sudden drop in efficacy ,if there is one,and the later observation

In addition to mast cells, the effect of luteolin treatment on basophils has been investigated [170]

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At higher concentrations, cocaine also blocks different voltage gated channels in a state-dependent manner with a higher affinity for inactivated and open states vs rested/closed states of the channels