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Similar content being viewed by others Introduction The presence of the blood-brain barrier (BBB), a tightly interconnected network of blood vessels and endothelial cells that restricts the entry of foreign particles larger than 100 nm into the brain, poses considerable challenges and complexities in advancing therapeutic strategies for neurodegenerative diseases (NDs) 1
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2 Nevertheless, it is emerging that static structures determined via x-ray crystallography or cryo-electron microscopy (cryo-EM) cannot always be extrapolated to understand receptor and transducer activation, which are inherently dynamic processes
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