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These patients also exhibit polymorphisms to the serotonin receptor 2A region of chromosome 13 and the human leukocyte antigen region of chromosome 6, as well as abnormalities in catechol- O -methyltransferase

However, the condition may become irreversible if prolonged deficiency causes permanent follicle damage

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Patients whose pain lasts more than 3 months and who have 11 out of 18 tender-point sites are diagnosed with fibromyalgia syndrome

Vegans or those with a deficiency might need supplements