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Individuals with pre-existing kidney disease should consult their healthcare provider before supplementing

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If you want to assess your own metabolic baseline before any protocol, the key markers are: fasting insulin and fasting glucose (calculate HOMA-IR: glucose multiplied by insulin divided by 405, target below 2), high-sensitivity CRP (below 1), ferritin (50 to 100), free T3, and the triglyceride-to-HDL ratio (below 2)

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When used with a sulfonylurea or insulin, the care team may reduce doses of the companion medication to lower hypoglycemia risk