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This elevated baseline body weight and helped buffer against anticipated losses and pharmacological effect, allowing the research animals to complete the study without requiring dose holidays or protocol adjustments

David Kim: Received laboratory research support from the National Institutes of Health and contract funding from a small biotechnology company working on incretin analogs

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L-C19 patients developed endothelial dysfunction which, even if it had progressively improved after 6 months, the risk for thrombotic or cardiovascular events remained high

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