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It is a well-established but rarely celebrated fact that estradiol, and activity of the enzyme responsible for estradiol synthesis, P -450 aromatase, as well as estrogen receptors, are all at their highest levels in the brain either prenatally or during the first few days of life and then gradually decline to adult levels

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193 Cisplatin-based chemotherapy remains the primary treatment for advanced gastric cancer, however, chemotherapy resistance remains a significant challenge to clinical efficacy