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[3] [26] Diseases [edit] Combined malonic and methylmalonic aciduria (CMAMMA) [edit] In the metabolic disease combined malonic and methylmalonic aciduria (CMAMMA) due to ACSF3 deficiency, mitochondrial fatty acid synthesis (mtFAS), which is the precursor reaction of lipoic acid biosynthesis, is impaired

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doi: 10.1001/JAMA.2023.20294

Combined therapy with L-arginine and L-norvaline further enhances these effects by reducing IL-17A expression, lowering peroxynitrite-induced oxidative stress, and inhibiting iNOS activity to restore arginine metabolic balance [86]

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Zeta potential was recorded with one Nano-ZS Zetasizer ZEN 3600 (Malvern Instruments, England)